Quantifying technical load and physical activity in professional soccer players during pre-season matches with IMU technology.

This study aimed to record, analyze and quantify professional soccer players' technical (TL) and physical load (PL) in friendly matches to compare their records during the first and second halves and between players with different positions. Eighteen professional soccer players, 24.6 ± 2.7 years, 1.78 ± 0.3 height (m), 74.6 ± 4.5 body mass (kg), 9.8 ± 2.2 body fat (%), and 65.6 ± 2.7 maximal oxygen consumption (VO2max, ml·kg-1·min-1) were monitored during six preseason friendly matches to analyze the activity profile using technical and physical variables through inertial measurement unit (IMU). No significant differences were found between the periods for the TL and PL. Significant differences were found between specific positions: Full Back (FB: n = 4), Central Defender (CD: n = 3), Midfielder (MD: n = 4), Winger (WG: n = 4), and Forward (FW: n = 3), both the TL and PL. We conclude that the PL profile based on his playing position is independent of the development of the PL shown during friendly matches. The monitoring, quantifying, and controlling of the TL added to the PL provides a more holistic vision of soccer players in friendly matches. The relative ease IMU application technology offers an alternative with less time-cost and more significant benefits than other types of technologies applied up to now.

Oceanic and terrestrial origin of precipitation over 50 major world river basins: Implications for the occurrence of drought.

The terrestrial and oceanic origins of precipitation over 50 major river basins worldwide were investigated for the period 1980-2018. For this purpose, we used a Lagrangian approximation that calculates the humidity that results in precipitation from the entire ocean area (ocean component of the precipitation, PLO) and the entire land area (land component, PLT) as well as the sum of both components (Lagrangian precipitation, PL). PL and its components were highly correlated with precipitation over the basins, where PLT accounted for >50 % of the PL in most of them. This confirmed the importance assigned by previous studies to terrestrial recycling of precipitation and moisture transport within the continents. However, the amount of PLO in almost all North American river basins was highlighted. The assessment of drought conditions through the Standardized Precipitation Index (SPI) at a temporal scale of 1- and 3-months revealed the number of drought episodes that affected each river basin, especially the Amazon, Congo, and Nile, because of the lower number of episodes but higher average severity and duration. A direct relationship between the severity of drought episodes and the respective severity computed on the oceanic and terrestrial SPI series was also found for the majority of basins. This highlights the influence of the severity of the SPI of oceanic origin for most basins in North America. However, for certain basins, we found an inverse relationship between the severity of drought and the associated severity according to the SPI of oceanic or terrestrial origin, thus highlighting the principal drought attribution. Additionally, a copula analysis provided new information that illustrates the estimated conditional probability of drought for each river basin in relation to the occurrence of drought conditions of oceanic or terrestrial origin, which revealed the possible main driver of drought severity in each river basin.

Síndrome antifosfolípido no trombótico: manifestaciones inflamatorias hematológicas y neurológicas / Non thrombotic antiphospholipid syndrome: neurologic and hematologic inflammatory manifestations

RESUMEN El síndrome antifosfolípido (SAF) es una entidad caracterizada por la presencia de anticuerpos antifosfolípidos y características clínicas como la pérdida fetal recurrente y la trombosis venosa o arterial. El diagnóstico del SAF se realiza extrapolando criterios de clasificación que incluyen criterios clínicos y de laboratorio, con manifestaciones trombóticas en su gran mayoría. Sin embargo, hay una gran variedad de manifestaciones no trombóticas de la enfermedad no incluidas en los criterios de clasificación. Dichas manifestaciones "extra-criterio" son aquellas que, debido a su frecuencia y a la relevancia que tienen para la toma de decisiones, son hallazgos de valor. Entre ellas, destacan características inflamatorias en dominios como el hematológico, de las cuales la principal es la trombocitopenia. De las diferentes manifestaciones neurológicas, debido a su frecuencia o gravedad, resaltan la migraña, la epilepsia, la demencia y otras graves como la corea y la mielitis. En la presente revisión se reseña la información disponible sobre las manifestaciones de dos dominios frecuentes y relevantes "extra-criterio" del síndrome antifosfolípido: las hematológicas y las neurológicas.

SUMMARY Antiphospholipid syndrome (APS) is an entity defined for the presence of antiphospholipid antibodies and events such as recurrent fetal loss and arterial or venous thrombosis. APS diagnosis is made through classification criteria, including laboratory criteria and clinical manifestations (most of them being thrombotic manifestations). Nonetheless, there is a wide variety of non-thrombotic manifestations of APS, which are not included in classification criteria. These "noncriteria" manifestations are important for decision making, based on their frequency or clinical relevance. Among them, some domains stand out: the hematologic domain, being thrombocytopenia the main manifestation; and the neurological domain with different manifestations such as migraine, epilepsy, dementia and severe manifestations, such as chorea and myelitis. Therefore, in the present article, information concerning two of the most common "non-criteria" domains (neurological and hematological) of APS is reviewed.

Delphi-based recommendations for the management of cardiovascular comorbidities in patients with psoriatic arthritis and moderate-to-severe psoriasis.

The aim of this study was to generate practical recommendations to assist rheumatologists and dermatologists in the management of cardiovascular (CV) comorbidities in patients with moderate-to-severe psoriasis (MS-PSO) and psoriatic arthritis (PsA). A two-round Delphi study was conducted. A panel of experts rated their agreement with a set of statements (n = 52) on a nine-point Likert scale (1 = totally disagree; 9 = totally agree). Statements were classified as inappropriate (median 1-3), irrelevant (median 4-6) or appropriate (median 7-9). Consensus was established when at least two-thirds of the panel responded with a score within any one range. A total of 25 experts, 60% rheumatologists and 40% dermatologists, participated in two consultation rounds. There was overall unanimity on the appropriateness of an initial assessment for CV risk factors in all patients with MS-PSO and PsA. Most panelists (88.0%) also supported the evaluation of patients' psychological and physical status. Additionally, most panelists (72.2%) agreed on a novel sequential approach for the management of CV comorbidities. This sequence starts with the assessment of hypertension, diabetes and dyslipidemia along with the identification of depression and anxiety disorders. Once these factors are under control, smoking cessation programs might be initiated. Finally, if patients have not met weight loss goals with lifestyle modifications, they should receive specialized treatment for obesity. This study has drawn up a set of practical recommendations that will facilitate the management of CV comorbidities in patients with MS-PSO and PsA.

Using a multilayer perceptron in intraocular lens power calculation.

PURPOSE: To determine the capabilities of a multilayer perceptron (MLP) for calculating the power of an intraocular lens (IOL) to be implanted and in achieving a given postoperative stable refraction. SETTING: Cuban Institute of Ophthalmology, Havana, Cuba. DESIGN: Retrospective review. METHODS: The study comprised data of patients who had uneventful phacoemulsification cataract surgery with implantation of a biconvex acrylic foldable IOL (type RYCF, model Ocuflex) in the capsular bag over 6 years. Exclusion criteria were previous intraocular or refractive corneal surgery, any corneal disease, pathological or complicated cataracts, intraoperative complications, preoperative astigmatism beyond 3.0 diopters (D), postoperative corrected distance visual acuity worse than 20/40, missing postoperative refractive information, eyes with an axial length (AL) shorter than 19.36 mm, eyes with an AL longer than 27.0 mm, average corneal keratometry (K) power lower than 36.0 D or higher than 50.9 D, and refractive surprises greater than ±3.0 D. The data were used to train an MLP to predict the value of the IOL power required for attaining a given postoperative refraction. Using AL, K value, and predicted and real postoperative refraction as input data, the output of the MLP was the IOL power. RESULTS: The study comprised 15 728 eyes of 15 728 patients. The trained neural networks predicted the value of the implanted IOL with an error less than 0.5 D in more than 95% of patients, even for a case in which a surgeon was not included in the training process. CONCLUSIONS: The accuracy attained by the trained MLP is high, indicating the feasibility of a prospective study leading to a new method of predicting the IOL power in refractive surgery with an error lower than the current prediction methods.

Psiquiatría psicosomática del niño y adolescente con enfermedades crónicas digestivas / Psychosomatic psychiatry of the child and adolescent with chronic digestive diseases

Las enfermedades crónicas infantiles influyen negativamente en el desarrollo psicológico. Los niños y adolescentes con enfermedades crónicas digestivas presentan de forma predominante síntomas ansiosos y depresivos. Factores ambientales como el manejo de la sintomatología, la influencia de la respuesta de los pares o de la propia familia pueden determinar el manejo que de la enfermedad tenga el paciente. Estos aspectos son muy relevantes en enfermedades como la Enfermedad de Crohn, la Colitis Ulcerosa, el Dolor Abdominal Recurrente y los Vómitos Psicógenos. Los factores psicológicos que afectan a enfermedades médicas y/o la presencia comórbida de patología mental disminuyen la calidad de vida de estos pacientes afectando también al sistema familiar. La medicina psicosomática aborda estos aspectos de dichas patologías ayudando al paciente y a sus familias. Un abordaje integral por parte digestivo y de salud mental incrementa la salud percibida de los niños y adolescentes con patología digestiva crónica

Chronic childhood diseases negatively influence on the child's psychological development. Children and adolescents with chronic digestive diseases have predominantly anxious and depressive symptoms. Environmental factors such as management of gastrointestinal symptoms, the influence of the response of peers or family itself can determine the handling of the disease. These aspects are very important in diseases like Crohn's disease, ulcerative colitis, recurrent abdominal pain and psychogenic vomiting. Psychological factors affecting medical conditions and / or the presence of comorbid mental illness diminish the quality of life of these patients also the family system is affecting. Psychosomatic medicine addresses these aspects of these diseases helping patients and their families. A comprehensive approach to improving gastrointestinal and psychiatric symptoms increases the perceived health of children and adolescents with chronic digestive diseases

Psiquiatría psicosomática del niño y adolescente con enfermedades crónicas: enfermedades renales / Children and Adolescent Psychomatic Psychiatry: Kidney Diseases

Las enfermedades crónicas infantiles tienen una gran influencia no sólo en lo físico, sino también en el desarrollo psicológico de los niños y adolescentes. Las enfermedades renales son frecuentes en este grupo de edad, presentan fundamentalmente síntomas ansiosos y depresivos, baja autoestima, además de los efectos secundarios de la inmunosupresión. Debido a que son patologías de características crónicas, con gran impacto de los procedimientos diagnósticos y terapéuticos y el alto riesgo de hospitalizaciones para recibir el tratamiento idóneo, conllevan una alteración del funcionamiento (social, familiar, escolar) habitual de los niños y adolescentes. Por lo que es importante, un abordaje multidisciplinar en estos casos, debido a la influencia de los factores psicológicos para minimizar el impacto de la patología, mejorar el curso y la adherencia terapéutica en este tipo de enfermedades de características crónicas

Chronic childhood diseases have a major influence not only physically, but also in the psychological development of children and adolescents. Kidney disease is common in this age group basically have anxious and depressive symptoms , low self-esteem , in addition to the side effects of immunosuppression. Because features are chronic diseases with great impact of diagnostic and therapeutic procedures and the high risk of hospitalization to receive the best treatment, involve an alteration of the normal functioning of children and adolescents (social, family, school). So it is important a multidisciplinary approach in these cases, because the influence of psychological factors to minimize the impact of the disease, improve the course and adherence in such chronic diseases features

Muscle damage, inflammatory, immune and performance responses to three football games in 1 week in competitive male players.

PURPOSE: We examined effects of a three-game, 1-week microcycle (G1, G2, G3) on recovery of performance and inflammatory responses in professional male footballers. METHODS: Players were randomized into an experimental (EXP; N = 20) and a control group (CON; N = 20). Blood was drawn and repeated sprint ability (RSA), muscle soreness and knee range of motion (KJRM) were determined pre- and post-games and during recovery. RESULTS: High-intensity running during G2 was 7-14% less compared to G1 and G3. RSA declined in EXP by 2-9% 3 days post-game with G2 causing the greatest performance impairment. In EXP, game play increased muscle soreness (~sevenfold) compared to CON with G2 inducing the greatest rise, while KJRM was attenuated post-game in EXP compared to CON (5-7%) and recovered slower post G2 and G3 than G1. CK, CRP, sVCAM-1, sP-Selectin and cortisol peaked 48 h post-games with G2 eliciting the greatest increase. Leukocyte count, testosterone, IL-1ß and IL6 responses, although altered 24 h post each game, were comparable among games. Plasma TBARS and protein carbonyls rose by ~50% post-games with G2 eliciting the greatest increase 48 h of recovery. Reduced to oxidized glutathione ratio declined for 24 h post all games with G2 displaying the slowest recovery. Total antioxidant capacity and glutathione peroxidase activity increased (9-56%) for 48 h in response to game play. CONCLUSION: In summary, post-game performance recovery and inflammatory adaptations in response to a three-game weekly microcycle displayed a different response pattern, with strong indications of a largest physiological stress and fatigue after the middle game that was preceded by only a 3-day recovery.

Repeated Acceleration Ability (RAA): A New Concept with Reference to Top-Level Field and Assistant Soccer Referees.

PURPOSE: To perform an exploratory characterization of repeated sprint sequences (RSS) and repeated acceleration sequences (RAS) in top level soccer referees. METHODS: 7 field and 7 assistant referees were monitored during 2007 America's Soccer Cup with GPS technology. Sprints of >18 km·h(-1) and accelerations of >1.5 m·s(-2) were considered as high intensity activities. RSS and RAS were defined as a minimum of 3 consecutive bouts interspersed with a maximum of 45 s. RESULTS: Field and assistant referees performed substantially more accelerations than sprints. Neither field nor assistant referees recorded any RSS. In contrast, total distance performing RAS amounted to ∼37% and ∼20% of the total distance covered by accelerations during the entire match for field and assistant referees, respectively. Only field referees exhibited fatigue-related reductions in RAS characteristics between halves. CONCLUSION: The results of the present study would appear to support the appropriateness of a repeated acceleration ability (RAA) concept, instead of the repeated sprint ability (RSA) concept, in soccer referees. Further studies should assess RAS in referees and athletes of different team sports for designing better training exercises and physiological testing.

Caffeine-containing energy drink improves physical performance in female soccer players.

There is little information about the effects of caffeine intake on female team-sport performance. The aim of this study was to investigate the effectiveness of a caffeine-containing energy drink to improve physical performance in female soccer players during a simulated game. A double-blind, placebo controlled and randomized experimental design was used in this investigation. In two different sessions, 18 women soccer players ingested 3 mg of caffeine/kg in the form of an energy drink or an identical drink with no caffeine content (placebo). After 60 min, they performed a countermovement jump (CMJ) and a 7 × 30 m sprint test followed by a simulated soccer match (2 × 40 min). Individual running distance and speed were measured using GPS devices. In comparison to the placebo drink, the ingestion of the caffeinated energy drink increased the CMJ height (26.6 ± 4.0 vs 27.4 ± 3.8 cm; P < 0.05) and the average peak running speed during the sprint test (24.2 ± 1.6 vs 24.5 ± 1.7 km/h; P < 0.05). During the simulated match, the energy drink increased the total running distance (6,631 ± 1,618 vs 7,087 ± 1,501 m; P < 0.05), the number of sprints bouts (16 ± 9 vs 21 ± 13; P < 0.05) and the running distance covered at >18 km/h (161 ± 99 vs 216 ± 103 m; P < 0.05). The ingestion of the energy drink did not affect the prevalence of negative side effects after the game. An energy drink with a dose equivalent to 3 mg of caffeine/kg might be an effective ergogenic aid to improve physical performance in female soccer players.

Physiological demands of an intermittent futsal-oriented high-intensity test.

The aim of this study was to provide evidence for specific physiological demands of a futsal time-motion analysis devised progressive and intermittent shuttle-running test (futsal intermittent endurance test [FIET]). Eighteen full-time professional futsal players (age 20.6 +/- 3.1 years, body mass 71.6 +/- 8.5 kg, height 175 +/- 7.9 cm) volunteered to participate in this study. In a random order and on separate days, they performed the FIET and a treadmill test (TM) to assess aerobic fitness. Physiological demands were examined by monitoring exercise heart rates (HRs), O2, and blood-lactate concentration (BLac) during FIET and TM conditions. During the FIET, players covered 1,464 +/- 136 m attaining a mean speed at exhaustion of 16.5 +/- 0.6 km h. The mean FIET duration was of 13.24 +/- 1.13 minutes. Peak O2, HR, and BLac were 95 +/- 6.4, 99 +/- 2, and 108 +/- 25% of treadmill O2max, HRmax, and BLac, respectively. Large correlations were found between speed at ventilatory threshold and maximal speed at O2max with FIET performance (r = 0.60 and 0.61, p < 0.01, respectively). Peak O2 during the FIET was significantly lower than O2max. Although there was no mean difference between peak exercise HR in the TM and FIET conditions, significant intraindividual bias was evident. This study showed that FIET heavily stresses both the aerobic and anaerobic energy systems to a level that is similar to what was reported in futsal game play. Coaches may use the FIET to examine futsal players' ability to cope with intermittent high-intensity exercise. It is suggested that the highest HR found during the FIET should be regarded as peak HR and not as individual HRmax.

Effects of intermittent-endurance fitness on match performance in young male soccer players.

The purpose of this study was to examine the effect of specific endurance (Yo-Yo Intermittent recovery test level 1, Yo-Yo IR1) on match performance in male youth soccer. Twenty-one young, male soccer players (age 14.1 +/- 0.2 years) were involved in the study. Players were observed during international championship games of corresponding age categories and completed the Yo-Yo IR1 on a separate occasion. Physical (distance coverage) and physiological match demands were assessed using Global Positioning System technology and heart rate (HR) short-range telemetry, respectively. During the match (two 30-minutes halves), players covered 6,204 +/- 731 m, of which 985 +/- 362 m (16%) were performed at high intensities (speed >13 kmxh, HIA). A significant decrement (3.8%, p = 0.003) in match coverage was evident during the second half. No significant (p = 0.07) difference between halves was observed for HIA (p = 0.56) and sprint (speed >18 kmxh, SPR) distances. During the first and second halves, players attained the 86 +/- 5.5 and 85 +/- 6.0% of HRmax (p = 0.17), respectively. Peak HR during the first and second halves were 100 +/- 4 and 99.4 +/- 4.7% of HRmax, respectively. Yo-Yo IR1 performance (842 +/- 352 m) was significantly related to match HIA (r = 0.77, p < 0.001) and total distance (r = 0.65, p = 0.002). This study's results showed that specific endurance, as determined by Yo-Yo IR1 performance, positively affects physical match performance in male young soccer players. Consequently, the Yo-Yo IR1 test may be regarded as a valid test to assess game readiness and guide training prescription in male youth soccer players.

Aerobic fitness in futsal players of different competitive level.

Recently the use of small-sided games (mainly 5 vs. 5) proved to be a valid training method to improve aerobic fitness in soccer. Thus, it could be hypothesized that professional futsal (soccer 5-a-side indoor version) players may possess a well-developed aerobic fitness as a consequence of training and game participation. The aim of this study was to examine maximal oxygen uptake (VO2max), ventilatory threshold (VT), and running economy (RE, VO2 at 8 kmxh) of futsal players of different competitive levels to determine whether aerobic fitness is a discriminative variable for futsal success. Subjects were 24 male futsal players from a professional top-ranked second division team (PT, n = 11) and a semi-professional top-ranked third division team (ST, n = 13). Aerobic fitness was assessed with a running protocol performed on a motor-driven treadmill. Professional team and ST players' VO2max were 62.9 +/- 5.3 and 55.2 +/- 5.7 mLxkgxmin, respectively (p < 0.05). RE was 34.1 +/- 2.7 and 32.4 +/- 2.7 mLxkgxmin for PT and ST, respectively (p >0.05). PT and ST attained VT at 70.5 +/- 2.7 and 71.3 +/- 5.2% of VO2max, respectively (p > 0.05). Results showed that VO2max may be considered a competitive-level dependent physical variable in futsal. VO2max values of or above 60 mLxkgxmin are advisable to play futsal at the professional level.

Match demands of professional Futsal: a case study.

Despite its popularity and competitive status there have been only few scientific studies that have examined Futsal in professional players. Consequently the aim of this study was to examine the physiological responses and activity pattern to Futsal simulated game-play in professional players. Eight full-time professional outfield Futsal players volunteered for this study: age 22.4 (95% CI 18.8-25.3) years, body mass 75.4 (60-91) kg, height 1.77 (1.59-1.95) m and VO2max 64.8 (53.8-75.8) ml kg(-1) min(-1). Physiological measurements were assessed during highly competitive training games (4x10-min quarters) and consisted of game VO2, game blood-lactate concentration ([la](b)) and game heart rates (HRs). Game activities were assessed using a computerised video-analysis system. During simulated game-play players attained 75% (59-92) and 90% (84-96) of VO2max and HR(max), respectively. Mean game VO2 was 48.6 (40.1-57.1) ml kg(-1) min(-1). Peak game VO2 and HRs were 99% (88-109) and 98% [90-106] of laboratory maximal values, respectively. Players spent 46 and 52% of the playing time at exercise intensities higher than 80 and 90% of VO2max and HR(max), respectively. Mean [la](b) was 5.3 (1.1-10.4) mmol l(-1). Players covered 121 (105-137) m min(-1) and 5% (1-11) and 12% (3.8-19.5) of playing time spent performing sprinting and high-intensity running, respectively. On average players performed a sprint every approximately 79 s during play. These results show that Futsal played at professional level is a high-intensity exercise heavily taxing the aerobic and anaerobic pathways.

Effects of different practice conditions on acquisition, retention, and transfer of soccer skills by 9-year-old schoolchildren.

This study was designed to examine effects of three practice models, blocked, variable, and combined, on the acquisition, retention, and transfer of new motor skills. 67 subjects (M age = 9.5 yr., SD = .3) from the fourth year of primary school (31 boys and 26 girls) were assigned at random to three different practice groups (Blocked = 22, Variable = 23, Combined = 22) to study acquisition of two skills, dribbling a soccer ball and kicking a soccer ball at a stationary target using the dominant foot. All participants received a pretest and posttest, a transfer test, and a retention test 2 wk. later. Analysis showed significant improvement after practice of kicking skills by the three groups but not in the dribbling skills, for which only the combined practice group showed any notable improvement. At the end of acquisition, the combined practice group had significantly better performance on the dribbling task than the other two groups. However, the only differences noted in performance of kicking the ball with the dominant foot were by combined practice and blocked groups.

Carcinoma primário da vesícula biliar / Primary carcinoma of the gallbladder

São apresentados 23 casos de carcinoma primário da vesícula biliar no período de 1978 a 1990 no Hospital Universitário Gaffrée e Guinle. O objetivo foi estudar o enfoque atual dado a patologia com tão grande poder agressivo. A dificuldade no diagnóstico precoce, pela ausência de sinais e sintomas específicos, que raramente é feito, é destacado. São discutidas opções cirúrgicas para o tratamento, tanto curativo quanto paliativo desta patologia. Embora já empregado há anos, sem a divulgação necessária, o tratamento cirúrgico que impõe ressecção dos segmentos v e parte anterior do IV em monobloco com a vesícula tumoral e adequada linfadenectomia regional, mostra-se eficaz no tratamento de um percentual significativo de pacientes portadores de carcinoma primário da vesícula biliar. A radio e quimioterapia sem os resultados ainda esperados, devem ser utilizado como coadjuvantes, pois bons resultados são apresentados, embora esporádicos, na literatura consultada.

Lorazepam na ansiedade em gastroenterologia / Lorazepam in anxiety in gastroenterology

A açäo ansiolítica do lorazepam em gastroenterologia foi avaliada em 177 pacientes portadores de diagnósticos diversos nos quais a ansiedade apresentava participaçäo significativa. Observou-se rápida e acentuada reduçäo da ansiedade psicológica e somática e boa tolerabilidade. Os resultados obtidos, juntamente com os conhecimentos disponíveis sobre a farmacologia do lorazepam, demonstraram sua grande utilidade em gastroenterologia

Tratamento da úlcera duodenal com antiácido de alta potência / Duodenal ulcer treatment with high potency antacids

Foram avaliados 27 pacientes com diagnóstico endoscópico de úlcera duodenal ativa (estágio A1 ou A2 da classificaçäo da Sakita), submetidos a tratamento com antiácido de alta potência (7,06 mEq/ml) por seis semanas, analisando-se a eficácia e a tolerabilidade do esquema terapêutico. Este esquema constou de sete administraçöes diárias, 1 e 3 horas após as refeiçöes e ao deitar, de 5 a 10 ml do preparado antiácido. Os controles clínicos foram realizados na admissäo e nas 1ª, 2ª, 4ª e 6ª semanas de tratamento, enquanto os endoscópicos o foram na admissäo e ao final do estudo. A porcentagem de cura, ou seja, cicatrizaçäo da lesäo ulcerosas, atingiu 74,07% ao término do estudo. As análises clínicas revelaram reduçäo significativa da sintomatologia. A tolerabilidade foi boa, uma vez que somente três pacientes apresentaram reaçöes adversas (constipaçäo intestinal). Os autores discutem a importância da capacidade de neutralizaçäo ácida (potência antiácida) no tratamento da úlcera duodenal